标题：microRNAs in Spinal Cord Injury: Potential Roles and Therapeutic Implications
作者：Ning, Bin; Gao, Lu; Liu, Rong-Han; Liu, Yang; Zhang, Na-Sha; Chen, Zhe-Yu
作者机构：[Ning, Bin; Liu, Rong-Han] Shandong Univ, Jinan Cent Hosp, Dept Spinal Surg, Jinan 250012, Shandong, Peoples R China.; [Ning, Bin; Chen, Zhe-Yu] Sha 更多
通讯作者地址：[Chen, ZY]Shandong Univ, Sch Med, Dept Neurobiol, Shandong Prov Key Lab Mental Disorders, Jinan 250012, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
关键词：microRNA; spinal cord injury; therapy; diagnosis
摘要：microRNAs (miRNAs) are a novel class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. miRNAs can modulate gene expression and thus play important roles in diverse neurobiological processes, such as cell differentiation, growth, proliferation and neural activity, as well as the pathogenic processes of spinal cord injury (SCI) like inflammation, oxidation, demyelination and apoptosis. Results from animal studies have revealed the temporal alterations in the expression of a large set of miRNAs following SCI in adult rats, and the expressional changes in miRNAs following SCI is bidirectional (increase or decrease). In addition, several miRNAs have distinct roles in prognosis of SCI (protective, detrimental and varied). Taken together, the existing evidence suggests that abnormal miRNA expression following SCI contributes to the pathogenesis of SCI, and miRNAs may become potential targets for the therapy of SCI.