标题：Tuning the Solution-Mediated Concomitant Phase Transformation Outcome of the Piroxicam Monohydrate by Two Hydroxyl-Containing Additives: Hydroxypropyl Cellulose and H2O
作者：Yao, Changlin; Li, Yifan; Wang, Lei; Song, Shuang; Li, Bo; Liu, Yang; Tao, Xutang
作者机构：[Yao, Changlin; Wang, Lei; Song, Shuang; Li, Bo; Liu, Yang; Tao, Xutang] Shandong Univ, State Key Lab Crystal Mat, Minist Educ, Jinan 250100, Shandong 更多
通讯作者：Wang, Lei;Wang, L;Tao, XT
通讯作者地址：[Wang, L; Tao, XT]Shandong Univ, State Key Lab Crystal Mat, Minist Educ, Jinan 250100, Shandong, Peoples R China.
来源：CRYSTAL GROWTH & DESIGN
摘要：Solution-mediated concomitant phase transformation (SMCPT) of the Piroxicam (PCM) monohydrate was found. The PCM monohydrate could simultaneously transform to block Form I and needle Form II in acetone at 31 degrees C. However, the Form I and the Form II can be selectively grown in the presence of 0.04 mg/mL HPC and 1% H2O, respectively. In addition, the morphology of Form I is changed from block to rod-like or even needle with the increase of the concentration of HPC. Based on these phenomena, the roles of hydroxypropyl cellulose (HPC) and H2O in the solution-mediated concomitant phase transformation were studied. The mechanisms of HPC and H2O to affect the process of SMCPT of the PCM monohydrate are different. In the presence of 0.04 mg/mL HPC, the interactions between the HPC molecules and the PCM molecules was the main factor that governed the process of SMCPT of the PCM monohydrate. However, in the presence of 1% H2O, the driving force of SMCPT played the main role. In our work, the outcome of SMCPT could be tuned directly by additives for the first time, which provides a good guide to obtain the pure polymorph in the SMCPT for pharmaceutical industry.