标题：The effect of CPAP and PDE5i on erectile function in men with obstructive sleep apnea and erectile dysfunction: A systematic review and meta-analysis
作者：Li, Zeyan; Fang, Zhiqing; Xing, Naidong; Zhu, Shiqin; Fan, Yidong
作者机构：[Li, Zeyan; Fang, Zhiqing; Xing, Naidong; Fan, Yidong] Shandong Univ, Qilu Hosp, Dept Urol, Jinan 250012, Shandong, Peoples R China.; [Zhu, Shiqin] 更多
通讯作者：Fan, YD;Zhu, SQ
通讯作者地址：[Fan, YD]Shandong Univ, Qilu Hosp, Dept Urol, Wenhuaxi Rd 44, Jinan 250000, Shandong, Peoples R China;[Zhu, SQ]Shandong Univ, Shandong Prov Hosp, Ctr 更多
来源：SLEEP MEDICINE REVIEWS
关键词：Obstructive sleep apnea; Erectile dysfunction; Continuous positive; airway pressure; Phosphodiesterase type 5 inhibitors
摘要：Growing evidence has shown that obstructive sleep apnea (OSA) and erectile dysfunction (ED) often coexist. However, the effect of continuous positive airway pressure (CPAP) on erectile function remains controversial. The objective of this review was to clarify the anti-ED effect of CPAP and further compare the efficacy between CPAP, phosphodiesterase type 5 inhibitors (PDE5i) and combination therapy on erectile function in OSA patients concurrent ED. Literature search was performed up to December 1st, 2018 and 26 studies were included in the review. Results showed that CPAP significantly ameliorated the international index of erectile function (IIEF) score, total erectile events (TEE) and nocturnal penile rigidity (NPR), while no significant improvements in nocturnal penile tumescence circumference (NPTC). Moreover, CPAP was inferior to PDE5i in improving IIEF-erectile function, IIEF-intercourse satisfaction, NPTC, successful attempted intercourses rate (SAIR) and erectile dysfunction inventory of treatment satisfaction-question one (EDITS-Q1), while CPAP and PDE5i were of equal efficacy in other domains of IIEF and NPR. Interestingly, CPAP was more effective in improving TEE. Furthermore, CPAP combined with PDE5i was superior to CPAP alone in improving IIEF score, SAIR, and TEE. This review provided promising insights about CPAP-based ED treatment for OSA patients. (c) 2019 Elsevier Ltd. All rights reserved.