标题：Physical Exercise and Its Protective Effects on Diabetic Cardiomyopathy: What Is the Evidence?
作者：Zheng, Jia; Cheng, Jing; Zheng, Sheng; Zhang, Ling; Guo, Xiaohui; Zhang, Junqing; Xiao, Xinhua
作者机构：[Zheng, Jia; Xiao, Xinhua] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Minist Hlth, Key Lab Endocrinol,Dept Endocrinol, Beijing, Peoples R China 更多
通讯作者：Xiao, XH;Xiao, XH;Zhang, JQ
通讯作者地址：[Xiao, XH]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Minist Hlth, Key Lab Endocrinol,Dept Endocrinol, Beijing, Peoples R China;[Xiao, XH]Peking 更多
来源：FRONTIERS IN ENDOCRINOLOGY
关键词：exercise; diabetic cardiomyopathy; myocardial metabolism; oxidative; stress; myocardial fibrosis; apoptosis
摘要：As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM) imposes a huge burden on individuals and society, and represents a major public health problem. It has long been recognized that physical exercise has important health benefits for patients with type 2 diabetes, and regular physical exercise can delay or prevent the complications of diabetes. Current studies show that physical exercise has been regarded as an importantly non-pharmacological treatment for diabetes and DCM, with high efficacy and low adverse events. It can inhibit the pathological processes of myocardial apoptosis, myocardial fibrosis, and myocardial microvascular diseases through improving myocardial metabolism, enhancing the regulation of Ca2+, and protecting the function of mitochondria. Eventually, it can alleviate the occurrence and development of diabetic complications. Describing the mechanisms of physical exercise on DCM may provide a new theory for alleviating, or even reversing the development of DCM, and prevent it from developing to heart failure.