标题：Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model
作者：Ji,B.;Yang,Q.;Genever,P.G.;Fagan,M.J.
通讯作者：Ji, Bing
作者机构：[Ji, B] School of Control Science and Engineering, Shandong University, 17923 Jingshi Road, Jinan, 250061, China;[ Yang, Q] Shandong Provincial Hospit 更多[Ji, B] School of Control Science and Engineering, Shandong University, 17923 Jingshi Road, Jinan, 250061, China;[ Yang, Q] Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan, 250021, China;[ Genever, P.G] Department of Biology, University of York, Heslington, York, YO10 5DD, United Kingdom;[ Fagan, M.J] School of Engineering, University of Hull, Cottingham Road, Hull, HU6 7RX, United Kingdom 收起
来源：Bio-medical materials and engineering
出版年：2014
卷：24
期：6
页码：3373-3378
DOI：10.3233/BME-141160
关键词：Anti-tumour;Bisphosphonates;Computational model;MM-induced bone disease;Multiple myeloma
摘要：Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentiation of osteoclast precursors into mature osteoclasts, promoting osteoclast apoptosis and disrupting osteoclast function. However, it is still unclear whether bisphosphonates have an anti-tumour effect. In our previous work, a computational model was built to simulate the pathology of MM-induced bone disease. This paper extends this proposed computational model to investigate the efficacy of bisphosphonates treatment and then clear the controversy of this therapy. The extended model is validated through the good agreement between simulation results and experimental data. The simulation results suggest that bisphosphonates indeed have an anti-tumour effect.
