标题：STK39 Polymorphism Is Associated with Essential Hypertension: A Systematic Review and Meta-Analysis
作者：Xi, Bo; Chen, Man; Chandak, Giriraj R.; Shen, Yue; Yan, Li; He, Juan; Mou, Si-Hua
作者机构：[Xi, Bo] Shandong Univ, Sch Publ Hlth, Inst Maternal & Child Hlth Care, Jinan 250100, Peoples R China.; [Chen, Man] Chengdu Med Coll, Sch Lab Med, C 更多
通讯作者地址：[Mou, SH]Taizhou Municipal Hosp, Dept Clin Lab, Taizhou, Peoples R China.
摘要：Background: A recent genome-wide association study identified STK39as a candidate gene for blood pressure (BP) in Europeans. Subsequently, several studies have attempted to replicate the association across different ethnic populations. However, the results have been inconsistent.; Objective and Methods: We performed a meta-analysis to elucidate the association between the STK39 rs3754777 polymorphism (or proxy) and hypertension. Published literature from PubMed and Embase databases were retrieved and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed-or random-effects model.; Results: Using appropriate inclusion/exclusion criteria, we identified 10 studies that included 21, 863 hypertensive cases and 24, 480 controls from different ethnicities. The meta-analysis showed a significant association of STK39 rs3754777 variant with hypertension (OR = 1.10, 95% CI = 1.06-1.15, p = 7.95x10(-6)). Further subgroup analysis by ethnicity suggested that the association was significant in Europeans (OR = 1.08, 95% CI = 1.03-1.14, p = 0.002) and in East Asians (OR = 1.16, 95% CI = 1.07-1.25, p = 4.34x10(-4)), but not in Africans (OR = 1.01, 95% CI 0.80-1.27, p = 0.932). We further confirmed the positive association by sensitivity analysis. No publication bias was detected (Begg's test, p = 0.721; Egger's test, p = 0.744).; Conclusions: The present meta-analysis confirms the significant association of STK39 polymorphism with susceptibility to hypertension in Europeans and East Asians. Future studies should include gene-gene and gene-environment interactions to investigate the identified association.