标题：Role of signaling pathways and miRNAs in chronic lymphocytic leukemia
作者：Li Pei-pei; Wang Xin
作者机构：[Li, P.-P] Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China;[ Wang, X] Departme 更多
通讯作者地址：[Wang, X]Shandong Univ, Shandong Prov Hosp, Dept Hematol, Jinan 250021, Shandong, Peoples R China.
关键词：chronic lymphocytic leukemia;signal pathway;miRNA
摘要：Objective To summarize the recent findings of dysregulation of signaling pathways and miRNAs in chronic lymphocytic leukemia (CLL).Data sources We searched PubMed database with the keywords \"chronic lymphocytic leukemia\",\"signal pathway\",or \"miRNA\" for relevant articles in recent years.Study selection Research articles and reviews about signaling pathways and miRNAs in CLL were chosen for review.Results Dysregulation of signaling pathways,such as B cell receptor,toll-like receptor,PI3K,nuclear factor KB,notch signaling pathway,Wnt/Fzd signaling pathway,and Hedgehog and Janus kinases/signal transducers and activators of transcription signaling pathway,as the terminal events of the aberrant gene expression and the pro-survival effects of microenvironment,plays a crucial role in the process of CLL.miRNAs,a novel found noncoding RNA,which regulate gene expression at transcription or post-transcription level and correlate with pathogenesis of CLL provide us new avenues to better evaluating prognosis and therapy of it.Conclusion Further investigation of the dysregulation of signaling pathways and miRNAs and their relationship may provide us a new prospective to understand the pathogenesis of CLL and may provide us new strategies to resolve the clinical nodi in treatment of CLL.