标题:High-robustness intravascular photoacoustic endoscope with a hermetically sealed opto-sono capsule
作者:Wen, Xue; Lei, Peng; Xiong, Kedi; Zhang, Pengfei; Yang, Sihua
作者机构:[Wen, Xue; Lei, Peng; Xiong, Kedi; Yang, Sihua] South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Peoples R China 更多
通讯作者地址:Yang, SH (corresponding author), South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Peoples R China.; Yang, SH (co 更多
来源:OPTICS EXPRESS
出版年:2020
卷:28
期:13
页码:19255-19269
DOI:10.1364/OE.394781
摘要:The prevailing open-structure intravascular photoacoustic (IVPA) endoscope emits a gradually deformed laser beam with exposed optical or acoustical components bearing pollution and damage in arterial lumen. Deformed laser beam scanning, which causes a low excitation efficiency and serious deterioration of the transverse resolution, is a current big obstacle to the application of photoacoustic endoscopy in intravascular imaging. Hence, the stable and reliable IVPA endoscope is indispensable. In this letter, we designed a high-robustness intravascular photoacoustic (HR-IVPA) endoscope with a hermetically sealed opto-sono capsule. The distal end of the opto-sono capsule was integrated with miniaturized optics, including a customized C-Lens and a customized total-reflection prism (TRP). The TRP was first applied to a side-viewing IVPA endoscope, featuring a high-throughput energy coupling efficiency of 90% and a cut-off free damage threshold. The optical path structure of the endoscope, optimized using optical simulation tools, overcame the ambiguous focus shift caused by chromatic dispersion and achieved a waist size of 20 mu m as well as a focus depth of 4 mm in water at the wavelength of 1200 nm. The mass phantom experiments demonstrated that the HR-IVPA endoscope afforded repeatable IVPA images with a relatively constant signal-to-noise ratio (SNR) of about similar to 41.8 dB and a transverse resolution of about similar to 23 mu m. The imaging experiments of the stent and lipid further demonstrated the robustness and validated the imaging ability of the FIR-IVPA endoscope, which opens a new avenue for improving the endoscopic imaging capability, strengthening the credible detection of atherosclerotic cardiovascular disease. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
收录类别:EI;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087495171&doi=10.1364%2fOE.394781&partnerID=40&md5=9a4246996dae893119064cd6294095dc
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