标题：Negative regulation of TBK1-mediated antiviral immunity
作者机构：[Zhao, W] Department of Immunology, Shandong University, School of Medicine, 44 Wenhua Xi Rd., Jinan, Shandong 250012, China
通讯作者地址：[Zhao, W]Shandong Univ, Sch Med, Dept Immunol, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源：FEBS Letters: For the Rapid Publication of Short Reports in Biochemistry, Biophysics and Molecular Biology
摘要：TANK-binding kinase 1 (TBK1) plays pivotal roles in antiviral innate immunity. TBK1 mediates the activation of interferon regulatory factor (IRF) 3, leading to the induction of type I IFNs (IFN-??/??) following viral infections. TBK1 must be tightly regulated to effectively control viral infections and maintain immune homeostasis. TBK1 activity can be regulated in a variety of ways, such as phosphorylation, ubiquitination, kinase activity modulation and prevention of functional TBK1-containing complexes formation. Furthermore, multiple viruses have evolved elaborate strategies to circumvent IFN responses by targeting TBK1. Here we provide an overview of TBK1 in antiviral immunity and recent developments on the regulation of TBK1 activity. ? 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.