标题：Vascular endothelial growth factor and recurrent spontaneous abortion: A meta-analysis
作者机构：[Zhang, B] Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China;[ Dai, B] Department of Epidem 更多
通讯作者地址：[Wang, ZP]Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, 44 Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源：Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function
关键词：Gene polymorphism;Meta-analysis;Recurrent spontaneous abortion/miscarriage/pregnancy loss;Vascular endothelial growth factor
摘要：To evaluate the association between vascular endothelial growth factor (VEGF) gene polymorphisms and the risk of recurrent spontaneous abortion (RSA), a meta-analysis of published case-control studies for the VEGF gene polymorphisms (gene polymorphisms reported more than three times were selected) and the risk of RSA. Odds ratios (ORs) and 95% confidence intervals (CIs) for codominant, dominant and recessive genetic models were assessed by RevMan software. Eight studies with 2813 cases and 2830 controls were included in this meta-analysis. The pooled analysis showed that - 2578C/A, - 1154G/A polymorphisms of VEGF were not significantly associated with the risk of RSA neither under codominant model nor under dominant model, nor under recessive model. Whereas, for - 634G/C polymorphism, the pooled OR and 95% CI were 1.23 (1.01-1.49) under recessive model; and for 936C/T polymorphism, the pooled OR and 95% CI were 1.34 (1.07-1.67) and 1.40 (1.09-1.80) under codominant and dominant models, respectively. This meta-analysis suggested that VEGF gene - 2578C/A, - 1154G/A polymorphisms were not significantly associated with the risk of RSA, whereas, - 634G/C and +. 936C/T polymorphisms were associated with the risk of RSA under specific genetic models.