标题:Vascular endothelial growth factor and recurrent spontaneous abortion: A meta-analysis
作者:Zhang,B.;Dai,B.;Zhang,X.;Wang,Z.
作者机构:[Zhang, B] Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China;[ Dai, B] Department of Epidem 更多
通讯作者:Wang, ZP
通讯作者地址:[Wang, ZP]Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, 44 Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源:Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function
出版年:2012
卷:507
期:1
页码:1-8
DOI:10.1016/j.gene.2012.06.049
关键词:Gene polymorphism;Meta-analysis;Recurrent spontaneous abortion/miscarriage/pregnancy loss;Vascular endothelial growth factor
摘要:To evaluate the association between vascular endothelial growth factor (VEGF) gene polymorphisms and the risk of recurrent spontaneous abortion (RSA), a meta-analysis of published case-control studies for the VEGF gene polymorphisms (gene polymorphisms reported more than three times were selected) and the risk of RSA. Odds ratios (ORs) and 95% confidence intervals (CIs) for codominant, dominant and recessive genetic models were assessed by RevMan software. Eight studies with 2813 cases and 2830 controls were included in this meta-analysis. The pooled analysis showed that - 2578C/A, - 1154G/A polymorphisms of VEGF were not significantly associated with the risk of RSA neither under codominant model nor under dominant model, nor under recessive model. Whereas, for - 634G/C polymorphism, the pooled OR and 95% CI were 1.23 (1.01-1.49) under recessive model; and for 936C/T polymorphism, the pooled OR and 95% CI were 1.34 (1.07-1.67) and 1.40 (1.09-1.80) under codominant and dominant models, respectively. This meta-analysis suggested that VEGF gene - 2578C/A, - 1154G/A polymorphisms were not significantly associated with the risk of RSA, whereas, - 634G/C and +. 936C/T polymorphisms were associated with the risk of RSA under specific genetic models.
收录类别:SCOPUS;SCIE
WOS核心被引频次:9
Scopus被引频次:10
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865005594&doi=10.1016%2fj.gene.2012.06.049&partnerID=40&md5=1a914bae0787842e319c9340dbdbcfbd
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