标题：Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines
作者：Wang, Lei; Xu, Jianwei; Yan, Ye; Liu, Han; Li, Feng
作者机构：[Wang, Lei; Xu, Jianwei; Liu, Han; Li, Feng] Shandong Univ, Dept Gen Surg, Qilu Hosp, 107 West Rd, Jinan 250012, Shandong, Peoples R China.; [Yan, Y 更多
通讯作者：Li, F;Li, Feng
通讯作者地址：[Li, F]Shandong Univ, Dept Gen Surg, Qilu Hosp, 107 West Rd, Jinan 250012, Shandong, Peoples R China.
来源：ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
关键词：Gold nanoparticles; Panax notoginseng; PANC-1 cells; pancreatic cancer
摘要：Development of novel methods is needed for the synthesis of nanoparticles. Attention on such particles has elevated disquiet about the eco-friendly manner of their fabrication methods. In the present study, we equipped and synthesized gold nanoparticles (AuNPs) from Panax notoginseng; investigated as an environmentally friendly and non-toxic substrate. Amalgamation of AuNPs was distinguished by numerous studies such as UV-absorbance and it shows peak values in the range of 520-550 nm. Nanoparticles sizes are confirmed by dynamic light scattering analysis and it shows 100 nm. Moreover, transmission electron microscopy (TEM) and energy dispersive X-ray analysis (EDX) confirmed the shape of the Au particles present in the synthesized materials. FTIR analysis studies showed the active molecules positioned in the plane of the synthesized particles. The anticancer potential of AuNPs was evaluated in PANC-1 cells. Additionally, AuNPs efficiently induced cytotoxicity, ROS and apoptosis by intonating intrinsic apoptotic gene expressions in PANC-1 cells. Finally, our study confirmed the synthesis of AuNPs from Panax notoginseng, which showed anticancer effects in an environmentally friendly manner.