标题：Flow-injection-chemiluminescence method for the determination of penicillin G potassium
作者：Cao, W; Yang, JH; Sun, CX; Zhang, ZJ; Gao, QF
作者机构：[Cao, W; Yang, JH; Sun, CX; Zhang, ZJ; Gao, QF]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.;[Cao, W; Yang, 更多
会议名称：11th International Symposium on Luminescence Spectrometry - Detection Techniques in Biomedical and Environmental Analysis
会议日期：MAY 05-08, 2004
关键词：penicillin G potassium; chemiluminescence; flow-injection; potassium; permanganate; formaldehyde
摘要：The degradation product of penicillin G potassium can react with potassium permanganate in acidic medium and produce chemiluminescence, which is greatly enhanced by formaldehyde. The optimum conditions for this chemiluminescent reaction were studied in detail using a flow-injection system. The experiments indicated that under optimum conditions, the chemiluminescence intensity was linearly related to the concentration of penicillin G potassium within the range 1.0 x 10(-7)-1.0 x 10(-5) g/mL, with a detection limit (3 sigma) of 7 x 10(-8) g/mL. The relative standard deviation was 1.0% for 4.0 x 10(-7) g/mL penicillin G potassium solution (n = 11). This method has the advantages of simple operation, fast response and high sensitivity. The method was successfully applied to the analysis of penicillin G potassium in raw medicines. Copyright (c) 2005 John Wiley & Sons, Ltd.