标题：Expression of Tumor Necrosis Factor-alpha-induced Protein 8 in Pancreas Tissues and its Correlation with Epithelial Growth Factor Receptor Levels
作者：Liu, Ke; Qin, Cheng-Kun; Wang, Zhi-Yi; Liu, Su-Xia; Cui, Xian-Ping; Zhang, Dong-Yuan
作者机构：[Liu, Ke; Qin, Cheng-Kun; Wang, Zhi-Yi; Cui, Xian-Ping; Zhang, Dong-Yuan] Shandong Univ, Prov Hosp, Dept Hepatobiliary, Jinan 250100, Peoples R China. 更多
通讯作者地址：[Qin, CK]Shandong Univ, Prov Hosp, Dept Hepatobiliary, Jinan 250100, Peoples R China.
来源：ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
关键词：TNFAIP8; pancreatic cancer; immunohistochemistry; EGFR
摘要：Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 or TIPE) is a recently identified protein considered to be associated with carcinogenesis. To investigate its expression pattern in pancreatic cancer patients and to analyse its correlation with clinicopathological significance and the expression levels of epithelial growth factor receptor (EGFR), immunohistochemistry was performed to detect the TNFAIP8 and EGFR proteins in pancreatic cancers, pancreatitis tissues, and healthy controls. The results showed stronger staining of TNFAIP8 protein in pancreatic cancer tissues compared with normal pancreas tissue. Furthermore, in 56 patients with pancreatic cancer, the expression levels of TNFAIP8 in patients with low tumor stage was higher than that with high tumor stage, and correlated with tumor staging and lymph node metastasis (P<0.05). Furthermore, TNFAIP8 expression positively correlated with EGFR levels (r=0.671135, P<0.05). These results indicate that TNFAIP8 may play important roles in the progression of pancreatic cancer.