标题：FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies
作者：Liu, Hong-Da; Wang, Wen-bo; Xu, Zhi-gang; Liu, Chang-hong; He, Dong-fang; Du, Lv-Pei; Li, Min-Yong; Yu, Xiao; Sun, Jin-peng
作者机构：[Liu, Hong-Da; Wang, Wen-bo; He, Dong-fang; Sun, Jin-peng] Shandong Univ, Sch Med, Minist Educ, Key Lab Expt Teratol, Jinan 250100, Shandong, Peoples 更多
通讯作者地址：[Yu, X]Shandong Prov Sch Key Lab Prot Sci Chron Degenera, Jinan, Shandong, Peoples R China.
来源：EUROPEAN JOURNAL OF PHARMACOLOGY
关键词：GPR120; Glucose metabolism; Lipid; Arrestin; Biased signaling
摘要：Free Fatty Acid 4 receptor (FFA4 receptor or GPR120), a rhodopsin-like G protein coupled receptor (GPM) subfamily member, is a receptor that senses specific fatty acids such as omega-3 fatty acid in fish oil or the endogenous signaling lipid, PHASA. FFA4 receptor is enriched in lung, colon and adipose tissue but is also detected in many other tissues and cells. The activation of FFA4 receptor has multiple effects, including but not limited to inhibition of inflammation, improving insulin sensitivity and adipogenesis, and regulating hormone secretion from the gastro-intestinal system and pancreatic islets. The important role of FFA4 receptor in maintaining metabolic homeostasis strongly indicates the great potential of selective FFA4 receptor agonizts to treat diabetes and inflammation. In this review, we summarize recent research progress in the physiological and biochemical studies of FFA4 receptor and highlight its underlying signaling mechanisms and ligand identification to assist future research to exploit FFA4 receptor as a drug target. (C) 2015 Elsevier B.V. All rights reserved