标题：Understanding the roles of negative immune regulator TIPE2 in different diseases and tumourigenesis
作者：Li, Zequn; Jia, Wenyu; Niu, Jun; Zhang, Lining
作者机构：[Li, Zequn] Affiliated Hosp Qingdao Univ, Dept Gen Surg, Qingdao, Peoples R China.; [Jia, Wenyu] Shandong Univ, Shandong Prov Hosp, Dept Endocrinol, 更多
通讯作者：Niu, J;Zhang, LN
通讯作者地址：[Niu, J]Shandong Univ, Qilu Hosp, Dept Gen Surg, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China;[Zhang, LN]Shandong Univ, Sch Basic Med Sci 更多
来源：HISTOLOGY AND HISTOPATHOLOGY
关键词：TIPE2; Expression profile; Immune regulator; Inflammatory diseases;; Tumourigenesis
摘要：Tumour necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a novel identified negative regulator of both innate and adaptive immunity, which participates in immune homeostasis. TIPE2 is expressed in both immune tissues and nonimmune tissues. It is significantly down-regulated in patients with infectious and autoimmune diseases, and the depletion of TIPE2 causes severe inflammatory disease. In recent years, accumulating evidence has shown that TIPE2 serves as an ideal biomarker and as a tumour suppressor in several tumour types. In this review, we summarized the roles and corresponding mechanisms of TIPE2 in immune regulation and different diseases, especially in tumourigenesis.