标题:Parenteral nanosuspension of a novel synthesized antitumor candidate: Investigation of tissue biodistributions and plasma pharmacokinetics
作者:Tian, X.;Li, H.;Zhang, D.;Shen, J.;Jia, L.;Zheng, D.;Liu, G.;Hao, L.;Shen, Y.;Zhang, Q.
作者机构:Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, China;Department of Microbi
来源:Colloids and Surfaces, A. Physicochemical and Engineering Aspects
出版年:2013
页码:868-872
关键词:A novel synthesized p-terphenyl derivative;Biodistribution;Chemical stability;Nanosuspension;Pharmacokinetics
摘要:Previously, nanosuspension of a novel synthesized p-terphenyl derivative (H2,) with a mean particle size of 201.7. ±. 5.87. nm was prepared using precipitation-microfluidization method. Enhanced saturation solubility and accelerated dissolution velocity were achieved. The objectives of this current study were to investigate the tissue biodistribution and plasma pharmacokinetic properties of H2 nanosuspension comparing with that of H2 solution after intravenously administration to mice. In an attempt to ensure the drug content accuracy during the animal tests, chemical stability of H2 nanosuspension was also monitored over a 1 month period. As shown in the plasma concentration-time profiles, drug nanosuspensions were effective in increasing the plasma level of H2 compared to drug solution. In particular, the initial concentration of H2 administered as nanosuspension and solution were 13.05. μg/mL and 5.54. μg/mL, respectively. What\'s more, compared with H2 solution, nanosuspension significantly changed drug biodistribution features in tissues, relatively increased drug concentration in liver and lung, and decreased that in other tissues.
资源类型:期刊论文
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