标题:Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect
作者:Bai, Su-Yun; Dai, Xi; Zhao, Bao-Xiang; Miao, Jun-Ying
作者机构:[Bai, Su-Yun; Miao, Jun-Ying] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China.; [Dai, Xi; Zhao, Bao-Xiang] Shandong Univ, 更多
通讯作者:Zhao, BX
通讯作者地址:[Zhao, BX]Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China.
来源:RSC ADVANCES
出版年:2014
卷:4
期:38
页码:19887-19890
DOI:10.1039/c4ra01800a
摘要:A series of novel fluorescent pyrazoline coumarin derivatives were synthesized. From them, we screened a compound possessing strong growth inhibitory effects on lung cancer cells. By taking advantage of fluorescence combined with LC-MS/MS and chemoinformatics technique, we successfully identified HSP90 as the target of the compound.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:8
Scopus被引频次:8
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899805802&doi=10.1039%2fc4ra01800a&partnerID=40&md5=975d170b443d1da3406e773aa269abd8
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