标题:ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis
作者:Zhang, Yue Hui; Hao, Qing Qing; Wang, Xiao Yu; Chen, Xu; Wang, Nan; Zhu, Li; Li, Shu Ying; Yu, Qing Tao; Dong, Bo
作者机构:[Zhang, Yue Hui; Hao, Qing Qing; Wang, Xiao Yu; Chen, Xu; Wang, Nan; Zhu, Li; Li, Shu Ying; Yu, Qing Tao; Dong, Bo] Shandong Univ, Shandong Prov Hosp, 更多
通讯作者:Dong, B
通讯作者地址:[Dong, B]Shandong Univ, Shandong Prov Hosp, Jinan 250100, Shandong, Peoples R China.
来源:JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
出版年:2015
卷:16
期:2
页码:292-300
DOI:10.1177/1470320314542829
关键词:Atherosclerotic plaque; angiotensin-converting enzyme 2; losartan;; Ang-(1-7); signaling pathway
摘要:Introduction: Angiotensin-converting enzyme 2 (ACE2) is a new member of the renin-angiotensin system (RAS) and it has been proposed that ACE2 is a potential therapeutic target for the control of cardiovascular disease. The effect of losartan on the ACE2 activity in atherosclerosis was studied.; Methods: Atherosclerosis was induced in New Zealand white rabbits by high-cholesterol diet for 3 months. An Angiotensin II (Ang II) receptor blocker (losartan, 25 mg/kg/d) was given for 3 months. ACE2 activity was measured by fluorescence assay and the extent of atherosclerosis was evaluated by H&E and Oil Red O staining. In addition, the effect of losartan on ACE2 activity in smooth muscle cells (SMCs) in vitro was also evaluated.; Results: Losartan increased ACE2 activity in atherosclerosis in vivo and SMCs in vitro. Losartan inhibited atherosclerotic evolution. Addition of losartan blocked Ang II-induced down-regulation of ACE2 activity, and blockade of extracellular signal-regulated kinase (ERK1/2) with PD98059 prevented Ang II-induced down-regulation of ACE2 activity.; Conclusions: The results showed that ACE2 activity was regulated in atherosclerotic plaque by losartan, which may play an important role in treatment of atherosclerosis. The mechanism involves Ang II-AT1R-mediated mitogen-activated protein kinases, MAPKs (MAPKs) signaling pathway.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:3
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930907265&doi=10.1177%2f1470320314542829&partnerID=40&md5=3caf428d73a373610f52c19c35a105fd
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