标题：Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy
作者：Xue, Song; Hu, Man; Iyer, Veena; Yu, Jinming
作者机构：[Xue, Song] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, 575 Mingfu Rd, Jinan 250200, Shandong, Peoples R China.; [Xue, Song; Hu, Man; Yu, 更多
通讯作者：Yu, JM;Yu, JM;Yu, JM
通讯作者地址：[Yu, JM]Shandong Univ, Shandong Canc Hosp, Dept Radiat Oncol, 440 Jiyan Rd, Jinan 250117, Shandong, Peoples R China;[Yu, JM]Shandong Univ, Shandong Ca 更多
来源：JOURNAL OF HEMATOLOGY & ONCOLOGY
关键词：PD-1; PD-L1; Expression; Immunosuppressive; Treatment; Glioma
摘要：Gliomas are the most common type of primary brain tumor in adults. High-grade neoplasms are associated with poor prognoses, whereas low-grade neoplasms are associated with 5-year overall survival rates of approximately 85%. Despite considerable progress in treatment modalities, the outcomes remain dismal. As is the case with many other tumors, gliomas express or secrete several immunosuppressive molecules that regulate immune cell function. Programmed death-ligand 1 (PD-L1) is a coinhibitory ligand that is predominantly expressed by tumor cells. The binding of PD-L1 to its receptor PD-1 has been demonstrated to induce an immune escape mechanism and to play a critical role in tumor initiation and development. Encouraging results following the blockade of the PD-1/PD-L1 pathway have validated PD-L1 or PD-1 as a target for cancer immunotherapy. Studies have reported that the PD-1/PD-L1 pathway plays a key role in glioma progression and in the efficacy of immunotherapies. Thus, progress in research into PD-L1 will enable us to develop a more effective and individualized immunotherapeutic strategy for gliomas. In this paper, we review PD-L1 expression, PD-L1-mediated immunosuppressive mechanisms, and the clinical applications of PD-1/PD-L1 inhibitors in gliomas. Potential treatment strategies and the challenges that may occur during the clinical development of these agents for gliomas are also reviewed.