标题：Ultrasensitive Electrochemiluminescent Sensor for MicroRNA with Multinary Zn-Ag-In-S/ZnS Nanocrystals as Tags
作者：Zhang, Bin; Zhang, Fang; Zhang, Ping; Shen, Dazhong; Gao, Xuwen; Zou, Guizheng
作者机构：[Zhang, Bin; Zhang, Fang; Gao, Xuwen; Zou, Guizheng] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.; [Zhang, Ping; Sh 更多
通讯作者：Zou, GZ;Zou, Guizheng
通讯作者地址：[Zou, GZ]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.
摘要：For the screening of novel toxic-element-free and biocompatible electrochemiluminophores, electrochemiluminescence (ECL) of multinary nanocrystals (NCs) was investigated for the first time with Zn Ag In S (ZAIS) NCs as model. Aqueous soluble ZAIS NCs could bring out efficient reductive-oxidation ECL with tri-n-propylamine as coreactant, while coating the ZAIS NCs with a ZnS shell could reduce the surface defects of ZAIS NCs, and enable 6.7-fold enhanced ECL of ZAIS/ZnS NCs as compared to ZAIS NCs. ECL of ZAIS/ZnS NCs was about 4.2-fold that of ternary CuInS2/ZnS NCs, spectrally similar to that of Ru(bpy)(3)(2+) with maximum emission around 605 nm, and favorable for less electrochemical interference with a lowered triggering potential (similar to 0.95 V) than that of Ru(bpy)(3)(2+). An ultrasensitive ECL microRNA sensor was fabricated with ZAIS/ZnS NCs as tags, which could sensitively and selectively determine microRNA-141 with a wide linearity range from 0.1 fmol/L to 20 pmol/L and a low limit of detection at 50 amol/L (S/N = 3). Multinary NCs might provide a promising alternative to the traditional binary NCs for both electrochemiluminophore screening and NC ECL modulating.