标题:Ultrasensitive Electrochemiluminescent Sensor for MicroRNA with Multinary Zn-Ag-In-S/ZnS Nanocrystals as Tags
作者:Zhang, Bin; Zhang, Fang; Zhang, Ping; Shen, Dazhong; Gao, Xuwen; Zou, Guizheng
作者机构:[Zhang, Bin; Zhang, Fang; Gao, Xuwen; Zou, Guizheng] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.; [Zhang, Ping; Sh 更多
通讯作者:Zou, GZ;Zou, Guizheng
通讯作者地址:[Zou, GZ]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.
来源:ANALYTICAL CHEMISTRY
出版年:2019
卷:91
期:5
页码:3754-3758
DOI:10.1021/acs.analchem.9b00199
摘要:For the screening of novel toxic-element-free and biocompatible electrochemiluminophores, electrochemiluminescence (ECL) of multinary nanocrystals (NCs) was investigated for the first time with Zn Ag In S (ZAIS) NCs as model. Aqueous soluble ZAIS NCs could bring out efficient reductive-oxidation ECL with tri-n-propylamine as coreactant, while coating the ZAIS NCs with a ZnS shell could reduce the surface defects of ZAIS NCs, and enable 6.7-fold enhanced ECL of ZAIS/ZnS NCs as compared to ZAIS NCs. ECL of ZAIS/ZnS NCs was about 4.2-fold that of ternary CuInS2/ZnS NCs, spectrally similar to that of Ru(bpy)(3)(2+) with maximum emission around 605 nm, and favorable for less electrochemical interference with a lowered triggering potential (similar to 0.95 V) than that of Ru(bpy)(3)(2+). An ultrasensitive ECL microRNA sensor was fabricated with ZAIS/ZnS NCs as tags, which could sensitively and selectively determine microRNA-141 with a wide linearity range from 0.1 fmol/L to 20 pmol/L and a low limit of detection at 50 amol/L (S/N = 3). Multinary NCs might provide a promising alternative to the traditional binary NCs for both electrochemiluminophore screening and NC ECL modulating.
收录类别:EI;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062423042&doi=10.1021%2facs.analchem.9b00199&partnerID=40&md5=48c17869d08880daa77fc8cde1ab63ae
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