标题：Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs
作者：Xu, Jiangkang; Khan, Abdur Rauf; Fu, Manfei; Wang, Rujuan; Ji, Jianbo; Zhai, Guangxi
作者机构：[Xu, Jiangkang; Khan, Abdur Rauf; Fu, Manfei; Wang, Rujuan; Ji, Jianbo; Zhai, Guangxi] Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Minist Ed 更多
通讯作者：Zhai, Guangxi;Zhai, GX
通讯作者地址：[Zhai, GX]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, 44 WenhuaXilu, Jinan 250012, Shandong, Peoples R China.
来源：JOURNAL OF CONTROLLED RELEASE
关键词：Cell penetrating peptides; Membrane transduction; Disorders; Therapeutic; agents
摘要：The selective infiltration of cell membranes and tissue barriers often blocks the entry of most active molecules. This natural defense mechanism prevents the invasion of exogenous substances and limits the therapeutic value of most available molecules. Therefore, it is particularly important to find appropriate ways of membrane translocation and therapeutic agent delivery to its target site. Cell penetrating peptides (CPPs) are a group of short peptides harnessed in this condition, possessing a significant capacity for membrane transduction and could be exploited to transfer various biologically active cargoes into the cells. Since their discovery, CPPs have been employed for delivery of a wide variety of therapeutic molecules to treat various disorders including cranial nerve involvement, ocular inflammation, myocardial ischemia, dermatosis and cancer. The promising results of CPPs-derived therapeutics in various tumor models demonstrated a potential and worthwhile scope of CPPs in chemotherapy. This review describes the detailed description of CPPs and CPPs-assisted molecular delivery against various tissues and organs disorders. An emphasis is focused on summarizing the novel insights and achievements of CPPs in surmounting the natural membrane barriers during the last 5 years.