标题:Diterpenoids from the Chinese Liverwort Heteroscyphus tener and Their Antiproliferative Effects
作者:Lin, Zhao-Min; Guo, Yan-Xia; Wang, Shu-Qi; Wang, Xiao-Ning; Chang, Wen-Qiang; Zhou, Jin-Chuan; Yuan, Huiqing; Lou, Hongxiang
作者机构:[Lin, Zhao-Min; Wang, Shu-Qi; Wang, Xiao-Ning; Chang, Wen-Qiang; Zhou, Jin-Chuan; Lou, Hongxiang] Shandong Univ, Dept Nat Prod Chem, Key Lab Chem Biol 更多
通讯作者:Lou, HX
通讯作者地址:[Lou, HX]Shandong Univ, Dept Nat Prod Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, 44 West Wenhua Rd, Jinan 250012, Peoples R China.
来源:JOURNAL OF NATURAL PRODUCTS
出版年:2014
卷:77
期:6
页码:1336-1344
DOI:10.1021/np5000507
摘要:Four new ent-labdane diterpenoids, heteroscyphins A-D (1-4), and four known diterpenoids (5-8) were isolated from the Chinese liverwort Heteroscyphus tener (Steph.) Schiffn. The absolute configuration of compound 1 was defined by single-crystal X-ray diffraction using Cu K alpha radiation. Cytotoxicity tests revealed that compounds 3 and 5 exhibited modest activity against seven cancer cell lines. Compound 5 showed inhibitory effects on prostate cancer (PCa) cell proliferation but with less inhibition on nonneoplastic prostate epithelial cells. Compound 5 markedly caused cell growth arrest at the G0/G1 phase and induced cellular apoptosis through ROS-mediated DNA damage in PCa cells.
收录类别:SCOPUS;SCIE
WOS核心被引频次:7
Scopus被引频次:8
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903590192&doi=10.1021%2fnp5000507&partnerID=40&md5=bb2a41f0ac2e88de192e00da2c919cd0
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