标题:ADP-heptose: A new innate immune modulator
作者:Hu, Xinyuan; Yang, Chunhua; Wang, Peng George; Zhang, Gao-Lan
作者机构:[Hu, Xinyuan] Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China.; [Hu, Xinyuan] Shandong Univ, Natl Glycoengn Res Ctr, 更多
通讯作者:Zhang, GaoLan;Zhang, GL
通讯作者地址:[Zhang, GL]Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA.
来源:CARBOHYDRATE RESEARCH
出版年:2019
卷:473
页码:123-128
DOI:10.1016/j.carres.2018.12.011
关键词:ADP-Heptose; Biosynthesis; Innate immunity; LPS; Modulator
摘要:Lipopolysaccharide (LPS) is a well-known pathogen-associated molecular pattern (PAMP) produced by gram-negative bacteria. Previous studies showed that a key metabolic intermediate in LPS biosynthesis, D-glycero-beta-D-manno-heptose 1,7-bisphosphate (HBP), could activate the NF-kappa B pathway and trigger the innate immune responses. However, it was unclear whether HBP could be a novel PAMP and its pattern recognition receptor (PRR) is not fully understood. Very recently, the Shao group reported that another key metabolic intermediate in LPS biosynthesis, ADP-heptose, could be transported into mammalian cells and bind with ALPK1 (alpha-kinase 1), which leads to a series of strong immune responses. These findings broaden our understanding on bacterial metabolites as a new type of PAMP and these small molecules hold great potential to be applied in the development of novel immune modulators. This minireview focuses on the roles of ADP-heptose related metabolites in innate immunity.
收录类别:EI;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060339568&doi=10.1016%2fj.carres.2018.12.011&partnerID=40&md5=2182a1d9d0dda5d69651342e7b1979af
TOP