标题："Old Friends in New Guise": Exploiting Privileged Structures for Scaffold Re-Evolution/Refining
作者：Song, Yu'ning; Chen, Wenmin; Kang, Dongwei; Zhang, Qingzhu; Zhan, Peng; Liu, Xinyong
作者机构：[Chen, Wenmin; Kang, Dongwei; Zhan, Peng; Liu, Xinyong] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China.; 更多
通讯作者地址：[Zhan, P]Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China.
来源：COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
关键词：Drug design; drug repositioning; privileged structure; scaffold; re-evolution; scaffold refining
摘要：The attempts to increase novel drug productivity through creative discovery technologies have fallen short of producing the satisfactory results. For these reasons, evolved from the concept of drug repositioning, "privileged structure"-guided scaffold re-evolution/refining is a primary strategy to identify structurally novel chemotypes by modifying the central core structure and the side-chain of the existing active compounds, or to exploit undescribed bioactivites by making full use of readily derivatized motifs with well-established synthetic protocols. Herein, we review the basic tricks of exploiting privileged structures for scaffold re-evolution/refining. The power of this strategy is exemplified in the discovery of other new therapeutic applications by refining privileged structures in anti-viral agents.