标题：Precise intraoperative sentinel lymph node biopsies guided by lymphatic drainage in breast cancer
作者：Li, Xiaoyan; Chen, Sisi; Jiang, Liyu; Kong, Xiaoli; Ma, Tingting; Xu, Hong; Yang, Qifeng
作者机构：[Li, Xiaoyan; Chen, Sisi; Jiang, Liyu; Kong, Xiaoli; Ma, Tingting; Yang, Qifeng] Shandong Univ, Qilu Hosp, Dept Breast Surg, Jinan 250012, Shandong, P 更多
通讯作者：Yang, QF;Xu, H;Yang, QF
通讯作者地址：[Yang, QF]Shandong Univ, Qilu Hosp, Dept Breast Surg, Jinan 250012, Shandong, Peoples R China;[Xu, H]Chinese Armed Police Force, Gen Hosp, Dept Breast 更多
关键词：precise sentinel lymph node biopsy; trSLNs; breast cancer
摘要：The purpose of this study was to present a novel surgical method for intraoperative precise sentinel lymph node biopsy (SLNB) and to determine its clinical efficacy and sensitivity in breast cancer patients. The sentinel lymph nodes (SLNs) were preoperatively evaluated by axillary ultrasound. The intraoperative detection of SLNs was guided by lymphatic drainage pathway. The lymphatic vessels and SLNs were visualized. During operation, we searched for all the true SLNs (trSLNs), para-SLNs (paSLNs) and post-SLNs (poSLNs) followed lymphatic drainage ducts. After precisely locating the lymphatic channels and lymph node, all the lymph nodes that firstly receive lymphatic drainage are designated as trSLNs. We precisely distinguished the trSLNs, paSLNs and poSLNs. We found the average number of trSLNs ranged from1 to 6. In addition, we assessed the novel technique in a total of 125 breast cancer patients. trSLNs were successfully identified in all patients (detection rate: 100 %). The accuracy of trSLNs is 99.2%. Data from our study strongly suggest that our method is a feasible and effective for the detection of precise trSLNs in breast cancer with real-time observations. (ClinicalTrials.gov number, NCT02651142).