标题:Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine.
作者:Jia M;Yang K;Fang H;Xu Y;Sun S;Su L;Xu W
作者机构:[Jia, M] Department of Medicinal Chemistry, School of Pharmacy, Shandong University, 44 West Culture Road, Ji'nan, Shandong 250012, China;[ Yang, K] D 更多
通讯作者:Xu, WF
通讯作者地址:[Xu, WF]Shandong Univ, Sch Pharm, Dept Med Chem, 44 W Culture Rd, Jinan 250012, Shandong, Peoples R China.
来源:Bioorganic and medicinal chemistry
出版年:2011
卷:19
期:17
页码:5190-5198
DOI:10.1016/j.bmc.2011.07.008
关键词:Aminopeptidase N inhibitors; Chloramphenicol amine derivatives;; Synthesis; QSAR
摘要:Aminopeptidase N (APN) is involved in different physiological and pathological processes of tumor cells, including proliferation, invasion, apoptosis and metastasis. Herein one series of compounds derived from commercially available (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol have been designed and synthesized. Furthermore, preliminary activity evaluation showed that some compounds elicited moderate inhibitory activity against APN with compounds 10e (IC(50)=6.1+/-0.5 muM) possessing the best efficacy, which could be used as the lead compound in the future for anticancer agents research.
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:6
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860389873&doi=10.1016%2fj.bmc.2011.07.008&partnerID=40&md5=e6d4fba4251b5242cb6be560254087aa
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