标题:Association between Metformin Use and Coronary Artery Calcification in Type 2 Diabetic Patients
作者:Lu, Yi; Wang, Yidong; Weng, Ting; Chen, Zexin; Sun, Xiujuan; Wei, Jia; Cai, Zhejun; Xiang, Meixiang
作者机构:[Lu, Yi; Wang, Yidong; Weng, Ting; Cai, Zhejun; Xiang, Meixiang] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Cardiol,Cardiovasc Key Lab Zhejiang P 更多
通讯作者:Cai, ZJ;Xiang, MX;Cai, ZJ;Cai, ZJ;Cai, ZJ
通讯作者地址:[Cai, ZJ; Xiang, MX]Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Cardiol,Cardiovasc Key Lab Zhejiang Prov, 88 Jiefang Rd, Hangzhou 310009, Zhejiang 更多
来源:JOURNAL OF DIABETES RESEARCH
出版年:2019
DOI:10.1155/2019/9484717
摘要:Objectives. Type 2 diabetes mellitus (T2DM) is associated with coronary artery calcification (CAC) which is an independent risk factor for cardiovascular events. Metformin is the first-line antidiabetic medication. We aimed to investigate the association between metformin use and CAC. Methods. We included 369 patients with T2DM in this cross-sectional study. CAC scores, clinical characteristics, and antidiabetic drug prescription information of the patients were acquired. Baseline parameters were balanced for metformin and nonmetformin users using the propensity score matching (PSM) strategy. Results. Among the 369 subjects who met our inclusion criteria, 288 subjects were included for further analysis after PSM. Metformin prescription rather than other antidiabetic medications was related to lower CAC scores (OR [95% CI] = 0.55 [0.34-0.90]; P=0.018). Further multivariable logistic regression analysis demonstrated that metformin was negatively associated with CAC severity (OR [95% CI] = 0.58 [0.34-0.99]; P=0.048), which was independent of age, BMI, eGFR, gender, cigarette smoking, duration of diabetes, hypertension, statin prescription, and number of nonmetformin antidiabetic agents. A subgroup analysis revealed a significant association between metformin and CAC scores in smokers (OR [95% CI] = 0.38 [0.16-0.93]; P=0.035), but the association was not observed in never-smokers (OR [95% CI] = 0.72 [0.34-1.51]; P=0.383). Conclusions. Metformin usage was independently associated with lower CAC scores in T2DM patients. The negative correlation between CAC scores and metformin was most prominent in patients with a history of cigarette smoking.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068104772&doi=10.1155%2f2019%2f9484717&partnerID=40&md5=8ef4c33706f0baac4f1e9632c9cd0987
TOP