标题：Structural characteristics and anticancer/antioxidant activities of a novel polysaccharide from Trichoderma kanganensis
作者：Lu, Yan; Xu, Lei; Cong, Yunzhe; Song, Ge; Han, Jun; Wang, Guodong; Zhang, Pengying; Chen, Kaoshan
作者机构：[Lu, Yan; Xu, Lei; Cong, Yunzhe; Song, Ge; Chen, Kaoshan] Shandong Univ, Sch Life Sci, 72 Binhai Rd, Qingdao 266000, Peoples R China.; [Zhang, Pengy 更多
通讯作者：Chen, Kaoshan;Chen, KS;Chen, KS
通讯作者地址：[Chen, KS]Shandong Univ, Sch Life Sci, 72 Binhai Rd, Qingdao 266000, Peoples R China;[Chen, KS]Shandong Univ, Natl Glycoengn Rechearch Ctr, 72 Binhai 更多
关键词：Trichoderma kanganensis; Polysaccharide; Structural characteristics;; Anticancer activity; Antioxidant activity
摘要：A novel water-soluble polysaccharide designated as TPS was isolated from the fermentation mycelia of Trichoderma kanganensis. TPS had a weight-average molecular mass of 3.074 x 10(5) Da, and the monosaccharide composition was consisted of Man (45.5%), G1cA (5.5%), Glc (10%), and Gal (39%). The major backbone of TPS was -> 6-alpha-D-Galp-1 -> 5-beta-D-Manf-1 -> 5,6-beta-D-Manf-1 -> 5,6-beta-D-Manf-1 ->, and the side chains are alpha-D-Glcp-1 -> 4-alpha-D-Glcp-1 ->, beta-D-Galf-1 ->, and alpha-D-Glcp-1 ->. In addition, we demonstrated that TPS was non-toxic in normal cells (LO2 cells) and inhibited the proliferation of mouse colon cells (CT26 cells). TPS also showed free radical scavenging activity against hydrogen peroxide. Overall, these results suggested that TPS from Trichoderma kanganensis may have potential application in biomedical fields.