标题：Effect of Fiberoptic Collimation Technique on 808 nm Wavelength Laser Stimulation of Cochlear Neurons
作者：Wang, Jingxuan; Lu, Jianren; Tian, Lan
作者机构：[Wang, Jingxuan; Lu, Jianren; Tian, Lan] Shandong Univ, Sch Informat Sci & Engn, Jinan 250100, Shandong, Peoples R China.
通讯作者地址：[Tian, L]Shandong Univ, Sch Informat Sci & Engn, Jinan 250100, Shandong, Peoples R China.
来源：PHOTOMEDICINE AND LASER SURGERY
摘要：Objective: The purpose of this study was to evaluate the effects of fiberoptic collimation technique on auditory neural stimulation in the cochlea with 808 nm wavelength lasers. Background data: Recently, the pulsed near-infrared lasers in the 800-1000 nm wavelength range have been investigated as an emerging technique to trigger auditory neural response in the cochlea. A laser beam divergence in the optical stimulation pathway exists, which may affect stimulation efficiency and spatial selectivity. Methods: The fiberoptic collimation technique was proposed for cochlear neuron stimulation, and the C-lens element was designed as the collimation structure. The spiral ganglion cells in deafened guinea pigs' cochlea were irradiated with collimated and uncollimated near-infrared lasers. Optically evoked auditory brainstem response (OABR) under the two laser output modes were recorded. Results: Laser with the collimation technique evoked an average 58% higher OABR amplitude than the uncollimated laser output. In addition, the collimated laser setup consumed on average 35.2% of laser energy compared with the uncollimated laser when evoking the same OABR amplitude. Conclusions: The fiberoptic collimation technique improved stimulation efficiency and reduced stimulating energy consumption in near-infrared neural stimulation in cochlea. The positive effects of laser collimation technique could benefit further research in optically based cochlear implants.