标题:Adverse events in treating smear-positive tuberculosis patients in China
作者:Zhang T.; Du J.; Yin X.; Xue F.; Liu Y.; Li R.; Luo C.; Li L.;等
作者机构:[Zhang, T] Department of Biostatistics, School of Public Health, Shandong University, Jinan, 250012, China;[ Du, J] Clinical Center Office, Beijing Tu 更多
通讯作者:Li, X(xjli@sdu.edu.cn)
通讯作者地址:[Li, X] Department of Biostatistics, School of Public Health, Shandong UniversityChina;
来源:International Journal of Environmental Research and Public Health
出版年:2015
卷:13
期:1
DOI:10.3390/ijerph13010086
关键词:Adverse events; China; Risk factors; Tuberculosis epidemiology
摘要:This study aimed to estimate the adverse events (AE) rate during anti-tuberculosis treatment and to explore AE-related risk factors. New and previously treated smear-positive tuberculosis (TB) cases were enrolled from eight regions in China between April 2009 and October 2010. The AE rate was estimated, and AE risk factors during anti-TB treatment were assessed using Cox proportional models. Among 2091 Chinese subjects with anti-TB treatment, 462 (22.1%, 95% confidence interval (CI), 20.3–23.9) patients developed AE, with liver injury and gastrointestinal reactions constituting the most common AE. Specifically, 9.8% (95% CI, 8.5–11.1) and 6.3% (95% CI, 5.3–7.4) developed liver injuries and gastrointestinal reactions, respectively. We found that AE rate differed by regions, TB knowledge score, symptoms score and smoking status. Liver injuries were associated with age, sex and smoking status; gastrointestinal reactions were associated with education level and symptom score. Improving patients’ knowledge on TB could reduce AE rate. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
收录类别:SCOPUS
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952802010&doi=10.3390%2fijerph13010086&partnerID=40&md5=c413ca66de32a55bff40dea2dbc7b8ca
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