标题:Effect of Smac and Taxol on non-small-cell lung cancer
作者:Peng, Chuanliang; Hao, Yingtao; Zhao, Yunpeng; Sun, Qifeng; Zhao, Xiaogang; Cong, Bo
作者机构:[Peng Chuanliang] Thoracic Department, The second Hospital of Shandong University, Jinan, Shandong 250033, China.;[Hao Yingtao] Thoracic Department, T 更多
通讯作者:Cong, B(pechuliang@126.com)
通讯作者地址:[Cong, B]Shandong Univ, Thorac Dept, Hosp 2, Jinan 250033, Peoples R China.
来源:生物化学与生物物理学报
出版年:2014
卷:46
期:5
页码:387-393
DOI:10.1093/abbs/gmu018
关键词:second mitochondria-derived activator of caspase; non-small-cell lung; cancer; invasive ability; apoptosis; cloning ability; chemosensitivity
摘要:A series of structurally unique second mitochondria-derived activator of caspases (Smacs) that act as antagonists of the inhibitor of apoptosis proteins (IAPs) directly have been discovered. They play crucial roles in mitochondrial apoptosis pathways and promote chemotherapy-induced apoptosis. In this study, we constructed a eukaryotic expression vector pcDNA3.1/Smac and transfected it into A549 human lung cancer cells. Then we analyzed the cell invasive and cloning ability, as well as cell apoptosis induced by Taxol. The results showed that over-expressed Smac significantly inhibited A549 cell invasive and cloning ability and promoted apoptosis following Taxol treatment. This finding provides a potential approach for the biological therapy of lung cancer.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:5
Scopus被引频次:5
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899885863&doi=10.1093%2fabbs%2fgmu018&partnerID=40&md5=56e8d255e4a3d151003905877dc865c1
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