标题:The Protective Effect of Stichopus Japonicus Fucoidan on PC12 Cells With Hypoxia/Reoxygenation Injury
作者:Song, Shuliang; Wang, Wei; Wang, Xiaochen; Liang, Hao; Wang, Yunshan; Ji, Aiguo
通讯作者:Ji, A G
作者机构:[Song, Shuliang; Wang, Wei; Wang, Xiaochen; Liang, Hao; Wang, Yunshan; Ji, Aiguo] Shandong Univ, Weihai Int Biotechnol R&D Ctr, Weihai 262409, Peoples 更多
会议名称:International Conference on Mechatronics Engineering and Computing Technology (ICMECT)
会议日期:APR 09-10, 2014
来源:MECHATRONICS ENGINEERING, COMPUTING AND INFORMATION TECHNOLOGY
出版年:2014
卷:556-562
页码:610-614
DOI:10.4028/www.scientific.net/AMM.556-562.610
关键词:Stichopus Japonicus; Fucoidan; Hypoxia/Reoxygenation Injury
摘要:In this study the effect of fucoidan SJP-3 extracted from Stichopus Japonicus was used to evaluate the protective effect on PC12 cells with hypoxia/reoxygenation injury. SJP-3 can stabilize the mitochondrial membrane potential and resistant Cyt-C/mitochondrial apoptotic pathway via increasing the Bcl-2 expression and decreasing expression of the Bax, caspase-3, caspase-9 suggesting that SJP-3 may exert a protective effects on neural cells with hypoxia/reoxygenation injury through the protection of mitochondria, the stability of mitochondrial membrane potential and inhibition of mitochondrial apoptosis pathway.
收录类别:CPCI-S;EI;SCOPUS
资源类型:会议论文;期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84902074644&doi=10.4028%2fwww.scientific.net%2fAMM.556-562.610&partnerID=40&md5=2804f71609de48939f99c735fcc9c552
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