标题：Chlamydia pneumoniae infection and cerebrovascular disease: a systematic review and meta-analysis
作者：Chen, Juan; Zhu, Meijia; Ma, Gaoting; Zhao, Zhangning; Sun, Zhongwen
作者机构：[Chen, Juan] Shandong Univ, Affiliated Qianfoshan Hosp, Dept Nephrol, Jinan 250014, Shandong, Peoples R China.; [Zhu, Meijia; Ma, Gaoting; Zhao, Zha 更多
通讯作者地址：[Zhu, MJ]Shandong Univ, Affiliated Qianfoshan Hosp, Dept Neurol, 66 Jingshi Rd, Jinan 250014, Shandong, Peoples R China.
关键词：Chlamydia pneumoniae; Infection; Cerebrovascular disease;; Atherosclerosis; Meta-analysis
摘要：Background: A wealth of published studies have been published on association between Chlamydia pneumoniae (C. pneumoniae) infection and cerebrovascular (CV) disease, but the results were inconsistent. This meta-analysis provides a systematic review of the available evidence from all serological and pathological studies of CV disease and C.pneumoniae.; Methods: A comprehensive research was conducted of MEDLINE, EMBASE, CNKI, WanFang technological periodical database and reference lists of articles to identify eligible case-control and cohort studies. Odds radio (OR) was calculated for each study outcome. Random effect model was used as pooling method and publication bias was estimated for the results.; Results: Fifty-two published studies that met criteria were selected. In case control studies, an association between C.pneumoniae infection and CV disease was revealed by serum specific IgG (OR, 1.61; 95% CI: 1.34 to 1.94), serum IgA (OR, 2.33; 95% CI: 1.76 to 3.08) and PCR technique of C.pneumoniae in peripheral blood cells (OR, 1.90; 95% CI: 1.17 to 3.07). No significant association was found in serum anti-C.pneumonae IgM seropositivity or in-situ-detection of C. pneumoniae in arterial biopsies with CV disease. Subgroup analysis by available studies suggested that C.pneumoniae may paly a role in atherosclerotic stroke, but be less significant in stroke of cardioembolism or other etiologies.; Conclusion: Association between C.pneumoniae infection and CV disease depends on the analytical method adopted, which seems stronger with stroke due to large artery atherosclerosis. Establishing a causal relationship between C.peumoniae infection and CV disease will require more prospective studies with combination of techniques and stratified by etiological subtypes.