标题：Lignans and Their Derivatives from Plants as Antivirals
作者：Cui, Qinghua; Du, Ruikun; Liu, Miaomiao; Rong, Lijun
作者机构：[Cui, Qinghua; Du, Ruikun; Liu, Miaomiao] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China.; [Cui, Qinghua; Du, Ruikun] S 更多
通讯作者：Cui, QH;Cui, QH;Cui, QH;Rong, LJ
通讯作者地址：[Cui, QH]Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China;[Cui, QH]Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese M 更多
关键词：lignans; antivirals; mechanism; drug development
摘要：Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans-podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals-are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.