标题：Bioreactor Substrate Feeding Control Using DO Stat Control Strategy: A modeling and Computer Simulation Study
作者：Gao, Ling; Lin, Yutian; Lin, Huibin; Jia, Xiaoyi; Lin, Jianqun; Lin, Jianqiang
通讯作者：Lin, J Q
作者机构：[Gao, Ling] Shandong Normal Univ, Sch Informat Sci & Engn, Shandong Prov Key Lab Distributed Comp Software N, Jinan 250014, Peoples R China.
会议名称：5th International Conference on Mechanical, Industrial, and Manufacturing Technologies (MIMT)
会议日期：MAR 10-11, 2014
来源：ENGINEERING AND MANUFACTURING TECHNOLOGIES
关键词：fedbatch; bioreactor; control; DO stat; modeling; simulation
摘要：In fermentation process, substrate concentration control is important in increasing product concentration, productivity and substrate yield so as to decrease the production cost. But, the feedback control of substrate concentration is difficult for the lack of sensor for online measurement of substrate concentration. In order to overcome above problem, dissolved oxygen (DO) stat strategy was developed for feedback control of glucose feeding in fedbatch fermentation using the abrupt increase of DO as the indicator for glucose depletion and glucose feeding. In this research, the DO stat control strategy for bioreactor control will be developed and the control process will be simulated. The simulation results indicate that the DO stat strategy is effective in glucose feeding control.