标题:Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a
作者:Hou, Zhaohua; Zhang, Jian; Han, Qiuju; Su, Chenhe; Qu, Jing; Xu, Dongqing; Zhang, Cai; Tian, Zhigang
作者机构:[Hou, Zhaohua; Zhang, Jian; Han, Qiuju; Su, Chenhe; Qu, Jing; Xu, Dongqing; Zhang, Cai] Shandong Univ, Sch Pharmaceut Sci, Inst Immunopharmaceut Sci, 更多
通讯作者:Zhang, J;Tian, ZG;Tian, ZG;Tian, ZG;Tian, ZG
通讯作者地址:[Zhang, J]Shandong Univ, Sch Pharmaceut Sci, Inst Immunopharmaceut Sci, Jinan, Peoples R China;[Tian, ZG]Zhejiang Univ, Affiliated Hosp 1, Coll Med,St 更多
来源:SCIENTIFIC REPORTS
出版年:2016
卷:6
DOI:10.1038/srep26150
摘要:Previous studies showed that hepatitis B virus (HBV), as a latency invader, attenuated host anti-viral immune responses. miRNAs were shown to be involved in HBV infection and HBV-related diseases, however, the precise role of miRNAs in HBV-mediated immunosuppression remains unclear. Here, we observed that down-regulated RIG-I like receptors might be one critical mechanism of HBV-induced suppression of type I IFN transcription in both HBV+ hepatoma cell lines and liver cancer tissues. Then, miR146a was demonstrated to negatively regulate the expression of RIG-I-like receptors by directly targeting both RIG-I and RIG-G. Further investigation showed that antagonizing miR146a by anti-sense inhibitors or sponge approach accelerated HBV clearance and reduced HBV load both in vitro and in a HBV-carrying mouse model. Therefore, our findings indicated that HBV-induced miR146a attenuates cell-intrinsic anti-viral innate immunity through targeting RIG-I and RIG-G, and silencing miR146a might be an effective target to reverse HBV-induced immune suppression.
收录类别:SCOPUS;SCIE
WOS核心被引频次:3
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971350180&doi=10.1038%2fsrep26150&partnerID=40&md5=b4f9d3fa92b41ca3dd8208b7351895f6
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