标题：Progressive muscle metaboreflex activation gradually decreases spontaneous heart rate baroreflex sensitivity during dynamic exercise
作者：Sala-Mercado, Javier A.; Ichinose, Masashi; Coutsos, Matthew; Li, Zhenhua; Fano, Dominic; Ichinose, Tomoko; Dawe, Elizabeth J.; O'Leary, 更多 作者机构：[Sala-Mercado, Javier A.; Ichinose, Masashi; Coutsos, Matthew; Li, Zhenhua; Fano, Dominic; Ichinose, Tomoko; O'Leary, Donal S.] Wayne State Univ, Sch 更多
通讯作者地址：[O'Leary, DS]Wayne State Univ, Sch Med, Dept Physiol, 540 E Canfield Ave, Detroit, MI 48201 USA.
来源：AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
关键词：exercise reflexes; pressor response; arterial baroreflex sensitivity
摘要：Sala-Mercado JA, Ichinose M, Coutsos M, Li Z, Fano D, Ichinose T, Dawe EJ, O'Leary DS. Progressive muscle metaboreflex activation gradually decreases spontaneous heart rate baroreflex sensitivity during dynamic exercise. Am J Physiol Heart Circ Physiol 298: H594-H600, 2010. First published December 4, 2009; doi:10.1152/ajpheart.00908.2009.-Ischemia of active skeletal muscle elicits a pressor response termed the muscle metaboreflex. We tested the hypothesis that in normal dogs during dynamic exercise, graded muscle metaboreflex activation (MMA) would progressively attenuate spontaneous heart rate baroreflex sensitivity (SBRS). The animals were chronically instrumented to measure heart rate (HR), cardiac output (CO), mean and systolic arterial pressure (MAP and SAP), and left ventricular systolic pressures (LVSP) at rest and during mild or moderate treadmill exercise before and during progressive MMA [via graded reductions of hindlimb blood flow (HLBF)]. SBRS [slopes of the linear relationships (LRs) between HR and LVSP or SAP during spontaneous sequences of >= 3 consecutive beats when HR changed inversely vs. pressure] decreased during mild exercise from the resting values (-5.56 +/- 0.86 vs. -2.67 +/- 0.50 beats.min(-1).mmHg(-1), P < 0.05), and in addition, these LRs were shifted upward. Progressive MMA gradually and linearly increased MAP, CO, and HR; linearly decreased SBRS; and shifted LRs upward and rightward to higher HR and pressures denoting baroreflex resetting. Moderate exercise caused a substantial reduction in SBRS (-1.57 +/- 0.38 beats.min(-1).mmHg(-1), P < 0.05) and both an upward and rightward resetting. Gradual MMA at this higher workload also caused significant progressive increases in MAP, CO, and HR and progressive decreases in SBRS, and the LRs were shifted to higher MAP and HR. Our results demonstrate that gradual MMA during mild and moderate dynamic exercise progressively decreases SBRS. In addition, baroreflex control of HR is progressively reset to higher blood pressure and HR in proportion to the extent of MMA.