标题：MicroRNAs: a critical regulator under mechanical force
作者：Wei, Fulan; Yang, Shuangyan; Wang, Songlin
作者机构：[Wei, Fulan; Yang, Shuangyan] Shandong Univ, Sch Stomatol, Dept Orthodont, Shandong Prov Key Lab Oral Tissue Regenerat, Jinan, Shandong, Peoples R Chi 更多
通讯作者：Wang, SL;Wei, FL
通讯作者地址：[Wang, SL]Capital Med Univ, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Sch Stomatol, Salivary Gland Dis Ctr,Mol Lab Gene Therapy & Too, Beijin 更多
来源：HISTOLOGY AND HISTOPATHOLOGY
关键词：MicroRNAs; Mechanical Force; Post-transcriptional regulator; Osteogenic; differentiation
摘要：Mechanical force is a kind of mechanical stimuli which actively participates in manipulating cellular activities in numerous types of cells. Progress in molecular and genetic research has uncovered various regulatory mechanisms underlying mechanical force-induced changes in cellular activities, which include both transcriptional regulation and post-transcriptional regulation. MicroRNAs (miRNAs) are 20-25 nucleotide (nt) non-coding RNAs which serve as post-transcriptional regulators of multiple physiological processes. To date, considerable research effort has focused on the expressions and functions of miRNAs in a wide range of biological and pathological processes, including but not limited to development, proliferation, metabolism and osteogenic differentiation. In this review, major emphasis is placed on the biogenesis, expressions and functions of miRNAs in a mechanical environment.