标题:NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses
作者:Jiang F.; Liu G.-S.; Dusting G.J.; Chan E.C.
作者机构:[Jiang, F] Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China;[ Liu, 更多
通讯作者:Jiang, F(fjiang@sdu.edu.cn)
通讯作者地址:[Jiang, F] Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China;
来源:Redox Biology
出版年:2014
卷:2
期:1
页码:267-272
DOI:10.1016/j.redox.2014.01.012
关键词:Fibrosis; NADPH oxidase; Nox4; Redox signaling; Transforming growth factor-β
摘要:Uncontrolled fibrosis in organs like heart, kidney, liver and lung is detrimental and may lead to end-stage organ failure. Currently there is no effective treatment for fibrotic disorders. Transforming growth factor (TGF)-β has a fundamental role in orchestrating the process of fibrogenesis; however, interventions directly targeting TGF-β would have undesired systemic side effects due to the multiple physiological functions of TGF-β. Further characterization of the downstream signaling pathway(s) involved in TGF-β-mediated fibrosis may lead to discovery of novel treatment strategies for fibrotic disorders. Accumulating evidence suggests that Nox4 NADPH oxidase may be an important downstream effector in mediating TGF-β-induced fibrosis, while NADPH oxidase-dependent redox signaling may in turn regulate TGF-β/Smad signaling in a feed-forward manner. It is proposed that pharmacological inhibition of the Nox4 function may represent a novel approach in treatment of fibrotic disorders. © 2014 The Authors.
收录类别:SCOPUS
Scopus被引频次:81
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893415235&doi=10.1016%2fj.redox.2014.01.012&partnerID=40&md5=e2c5d2efcbc95a0c452454aca0449f4e
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