标题：Thermal ablation for colorectal pulmonary metastases: a meta-analysis
作者：Liu, Jiannan; Wang, Shuhua; Sun, Ping; Liu, Aina; Zhang, Xiaofang; Gong, Wenjing; Liu, Ying; Kong, Xiangshuo; Zhang, Xuede
作者机构：[Liu, Jiannan; Sun, Ping; Liu, Aina; Gong, Wenjing; Liu, Ying; Kong, Xiangshuo] Yuhuangding Hosp, Dept Oncol, Yantai 264000, Shandong, Peoples R China 更多
通讯作者地址：[Zhang, XD]Beilun Dist Peoples Hosp Zhejiang Prov, Dept Oncol, Ningbo 315800, Zhejiang, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
关键词：Ablation; colorectal pulmonary metastases; meta-analysis; overall; survival
摘要：Previous studies have demonstrated ablation therapy is a safe and effective treatment in patients with pulmonary metastases from colorectal cancer, but the survival varied widely. The aim of this meta-analysis was to evaluate the overall efficacy of ablation therapy for colorectal pulmonary metastases (CPM). A total of 18 studies were included in this meta-analysis. Six of the studies were prospective, others were retrospective. Primary outcomes were the overall survival (OS), progression-free survival (PFS) and local control rate (LCR). The 1-, 2-, 3-, 4-, 5-year OS of CPM treated with ablation were 88.9%, 66.6%, 56.9%, 31.0%, 43.4% respectively. The 1-, 3-, 5-year PFS of CPM treated with ablation were 52.4%, 15.8%, 11.8% respectively. The 1-, 3-, 5-year LCR of CPM were 86.8%, 76.7%, 76.1% respectively. CPM patients after pulmonary ablation had a similar survival outcome with pulmonary metastasectomy. The data from the subgroups (tumor size <= 3 cm, without extrapulmonary metastasis and CEA negative) showed significantly better 1-year OS and 3-year OS in CPM patients who received pulmonary ablation. CPM with a single tumor had a better 3-year OS than those with multiple tumors, while their 1-year OS had no statistical difference. Those patients of CPM with a tumor size <= 3 cm, a single tumor, normal CEA level and without extrapulmonary metastasis are most likely to benefit from ablation treatment.