标题：The effect of granulocyte and granulocyte-macrophage colony stimulating factors on tumor promotion
作者：Liu, Qiqi; Qiao, Lili; Hui, Pingping; Deng, Guodong; Zhang, Jingxin; Liang, Ning; Xie, Jian; Zhang, Jiandong
作者机构：[Liu, Qiqi; Deng, Guodong] Shandong Univ, Qianfoshan Hosp, Dept Radiat Oncol, 16766 Jingshi Rd, Jinan 250014, Peoples R China.; [Qiao, Lili] Fifth P 更多
通讯作者地址：[Zhang, JD]Shandong Univ, Qianfoshan Hosp, Dept Radiat Oncol, 16766 Jingshi Rd, Jinan 250014, Peoples R China.
来源：JOURNAL OF BUON
关键词：cancer; G-CSF; GM-CSF; progression; tumorigenesis
摘要：GM-CSF and G-CSF are capable to regulate the maturation of undifferentiated multipotent stem cells into mature granulocytes, macrophages and T cells in the bone marrow. Thereby, clinicians correct neutropenia induced by chemotherapy or radiation routinely with recombinant G- or GM-CSFs in clinical practice. However, relevant studies found that treatment for cancer patients with adjuvant G-/GM-CSF would occasionally enhance the progression of tumors. Besides, constitutive production of G-CSF or GM-CSF by lung cancer cells could stimulate the growth or the invasion of tumor and result in protecting the tumor against unfavorable environment. These findings convinced researchers that G-/GM-CSF overexpression has a positive effect on malignant tumor progression. The purpose of this article was to explore the most recent research and the mechanisms of GM-CSF and G-CSF-induced tumor promotion and their clinical therapeutic applications.