标题：Development of the human fetal hippocampal formation during early second trimester
作者：Ge, Xinting; Shi, Yonggang; Li, Junning; Zhang, Zhonghe; Lin, Xiangtao; Zhan, Jinfeng; Ge, Haitao; Xu, Junhai; Yu, Qiaowen; Leng, Yu 更多 作者机构：[Ge, Xinting; Zhang, Zhonghe; Lin, Xiangtao; Zhan, Jinfeng; Ge, Haitao; Xu, Junhai; Yu, Qiaowen; Leng, Yuan; Feng, Lei; Meng, Haiwei; Tang, Yuchun; Li 更多
通讯作者地址：[Toga, AW]Univ So Calif, Keck Sch Med, Inst Neuroimaging & Informat, Lab Neuroimaging, Los Angeles, CA 90033 USA.
关键词：High resolution MRI; Fetal brain development; Hippocampal formation;; Shape analysis
摘要：Development of the fetal hippocampal formation has been difficult to fully describe because of rapid changes in its shape during the fetal period. The aims of this study were to: (1) segment the fetal hippocampal formation using 7.0 T MR images from 41 specimens with gestational ages ranging from 14 to 22 weeks and (2) reveal the developmental course of the fetal hippocampal formation using volume and shape analyses. Differences in hemispheric volume were observed, with the right hippocampi being larger than the left. Absolute volume changes showed a linear increase, while relative volume changes demonstrated an inverted-U shape trend during this period. Together these exhibited a variable developmental rate among different regions of the fetal brain. Different sub-regional growth of the fetal hippocampal formation was specifically observed using shape analysis. The fetal hippocampal formation possessed a prominent medial-lateral bidirectional shape growth pattern during its rotation process. Our results provide additional insight into 3D hippocampal morphology in the assessment of fetal brain development and can be used as a reference for future hippocampal studies. (C) 2015 Elsevier Inc. All rights reserved.