标题：Pharmacophore conjugation strategy for multi-targeting metal-based anticancer complexes
作者：Zhao Y.; Yang Y.; Xu F.; Zheng W.; Luo Q.; Zhang Y.; Jia F.; Wang F.
作者机构：[Zhao, Y] Beijing National Laboratory for Molecular Sciences;[ CAS Research/Education Center for Excellence in Molecular Sciences] Institute of Chemis 更多
通讯作者地址：[Zhao, Y] Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; Beijing Centre for Mas 更多
来源：Advances in Inorganic Chemistry
关键词：Anticancer agents; DNA binding; EGFR inhibition; Metal complexes; Multi-targeting
摘要：Metal-based anticancer drugs play a very important role in clinical therapy. Classical platinum anticancer drugs bind to DNA, causing various kind of DNA damage so as to induce the cancer apoptosis. However, severe side effects and inherited or acquired resistance limit their application. As cancers are multiple factor induced diseases, drugs that act at multiple targets may exert higher efficacy and lower resistance. In recent years, multi-targeting anticancer drugs attract broad attention in drug development. Pharmacophore conjugation strategy is one of the most important way to design and obtain multi-targeting drugs. Its application in developing novel metal-based multi-targeting anticancer agents will be discussed in detail. © 2020 Elsevier Inc.