标题:Reversal of hepatitis B virus-induced systemic immune tolerance by intrinsic innate immune stimulation
作者:Han, Qiuju; Lan, Peixiang; Zhang, Jian; Zhang, Cai; Tian, Zhigang
通讯作者:Tian, ZG
作者机构:[Han, Qiuju; Lan, Peixiang; Zhang, Jian; Zhang, Cai; Tian, Zhigang] Shandong Univ, Inst Immunopharmacol & Immunotherapy, Sch Pharmaceut Sci, Jinan 250 更多
会议名称:7th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis
会议日期:SEP 06-07, 2012
来源:JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
出版年:2013
卷:28
页码:132-137
DOI:10.1111/jgh.12034
关键词:HBV; immune tolerance; intrinsic immunity
摘要:Systemic immune tolerance induced by chronic hepatitis B virus (HBV) infection is a significant question, but the mechanism of which remains unclear. In this mini-review, we summarize the impaired innate and adaptive immune responses involved in immune tolerance in chronic HBV infection. Furthermore, we delineate a novel dual functional small RNA to inhibit HBV replication and stimulate innate immunity against HBV, which proposed a promising immunotherapeutic intervention to interrupt HBV-induced immunotolerance. A mouse model of HBV persistence was established and used to observe the immune tolerant to HBV vaccination, the cell-intrinsic immune tolerance of which might be reversed by chemically synthesized dual functional small RNA (3p-hepatitis B Virus X gene [HBx]-small interfering RNA) in vitro experiments and by biologically constructed dual functional vector (single-stranded RNA-HBx-short hairpin RNA) in vivo experiment using HBV-carrier mice.
收录类别:CPCI-S;SCOPUS;SCIE
WOS核心被引频次:5
Scopus被引频次:6
资源类型:会议论文;期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880396353&doi=10.1111%2fjgh.12034&partnerID=40&md5=536fb1f1f327caccfefc384daa57dad4
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