标题:Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-kappa B signaling pathway in a human breast cancer cell line
作者:Lin, X.; Zhang, X.; Wang, Q.; Li, J.; Zhang, P.; Zhao, M.; Li, X.
作者机构:[Lin, X.; Wang, Q.; Li, J.; Zhao, M.] Shandong Univ, Dept Pathol, Prov Hosp, Jinan 250021, Peoples R China.; [Zhang, X.] Shandong Univ, Dept Pathol, 更多
通讯作者:Wang, Q
通讯作者地址:[Wang, Q]Shandong Univ, Dept Pathol, Prov Hosp, Jinan 250021, Peoples R China.
来源:NEOPLASMA
出版年:2012
卷:59
期:3
页码:248-256
DOI:10.4149/neo_2012_032
关键词:perifosine; PI3K/Akt; breast cancer; multidrug resistant gene 1;; P-glycoprotein
摘要:P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is the major clinical impediment to chemotherapy of breast cancers. Down-regulation of PI3K/Akt pathway has been described as related to reversal of MDR in cancer cells. Here, we investigated the reversal effect on MDR phenotype of perifosine, a new Akt inhibitor, in breast cancer cell lines. In this study, MCF-7/ADM cells and MCF-7 cells were treated with different concentrations of perifosine. Our results suggested that perifosine reversed MDR partially by downregulation of P-gp expression and inhibition of PI3K/Akt/NF-kappa B pathway in the MCF-7/ADM cell line. The novel Akt inhibitor perifosine may be a promising new drug due to its ability to reverse MDR in human breast cancer cells.
收录类别:SCOPUS;SCIE
WOS核心被引频次:29
Scopus被引频次:32
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865282157&doi=10.4149%2fneo_2012_032&partnerID=40&md5=74de3af64d7aa16634a9a7026cf58a7a
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