标题:Asymmetric Aza-Henry Reaction of Indolenines Mediated by a Cinchona-Alkaloid-Thiourea Organocatalyst
作者:Shao, You-Dong; He, Xiu-Yan; Han, Dan-Dan; Yang, Xin-Ru; Yao, Hai-Bin; Cheng, Dao-Juan
作者机构:[Shao, You-Dong; He, Xiu-Yan; Han, Dan-Dan; Yang, Xin-Ru; Yao, Hai-Bin; Cheng, Dao-Juan] Heze Univ, Sch Chem & Chem Engn, Heze 274015, Peoples R China 更多
通讯作者:Cheng, DJ
通讯作者地址:[Cheng, DJ]Heze Univ, Sch Chem & Chem Engn, Heze 274015, Peoples R China.
来源:ASIAN JOURNAL OF ORGANIC CHEMISTRY
DOI:10.1002/ajoc.201900504
关键词:aza-Henry reaction; enantioselectivity; 3H-indoles; indolines;; organocatalysis
摘要:An organocatalytic asymmetric aza-Henry reaction of indolenines with nitromethane is presented. By using a Cinchona-alkaloid-based thiourea bifunctional organocatalyst, a series of structurally novel and optically active 2-nitromethyl indolines were afforded in synthetically useful yields (up to 91%) and good to high enantioselectivities (up to 94% ee). The developed protocol provides a powerful approach for the transformation of unactivated five-membered cyclic aldimines into valuable chiral N-heterocycles.
收录类别:SCIE
资源类型:期刊论文
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