标题：A versatile Pt-Ce6 nanoplatform as catalase nanozyme and NIR-II photothermal agent for enhanced PDT/PTT tumor therapy [多功能Pt-Ce6纳米平台作为过氧化氢纳米酶和 NIR-II光热剂用于增强PDT/PTT肿瘤治疗]
作者：Chen Q.; He S.; Zhang F.; Cui F.; Liu J.; Wang M.; Wang D.; Jin Z.;等
作者机构：[Chen, Q] Department of Life and Chemistry, Zhejiang Normal University, Jinhua, 321004, China;[ He, S] Department of Life and Chemistry, Zhejiang Norm 更多
通讯作者地址：[Jin, Z] Department of Life and Chemistry, Zhejiang Normal University, Department of Life and Chemistry, Zhejiang Normal UniversityChina;
来源：Science China Materials
关键词：catalase; cell apoptosis mechanisms; hypoxia; photodynamic; photothermal therapy
摘要：The hypoxic nature of solid tumors has severely negative effects on oxygen-based photodynamic therapy. In this study, we used porous Pt nanoparticles as a catalase (CAT) nanozyme, the second near-infrared (NIR-II) region photothermal transition agents (PTAs), and carriers of photosensitizer chlorin e6 (Ce6) to synthesize a composite nanosystem Pt-Ce6. In this system, Pt-Ce6 can continuously and stably decompose H2O2 into oxygen, thereby alleviating tumor hypoxia and improving the effect of photodynamic therapy (PDT). With 650 nm illumination, the reactive oxygen species (ROS) produced by Ce6 will decrease the mitochondrial membrane potential (MMP, ΔΨm) to release cytochrome c (Cyt-c) from the mitochondria into the cytoplasm, eventually leading to mitochondrial-mediated cellular apoptosis during the PDT process. In addition, Pt-Ce6 has good photothermal stability and high photothermal conversion efficiency (52.62%) in the NIR-II region. In U14 tumor-bearing mice, Pt-Ce6 completely suppressed tumor growth and recurrence under laser irradiation. Thus the nanocomposite shows excellent PDT/photothermal therapy (PTT) synergistic performance in vitro and in vivo. © 2020, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.