标题：Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct
作者：Jiao, P.;Zhou, H.;Otto, M.;Mu, Q.;Li, L.;Su, G.;Zhang, Y.;Butch, E.R.;Snyder, S.E.;Jiang, G.;Yan, B.
作者机构：[Jiao, P] School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China, Departments of Chemical Biology and Therapeutics, St. 更多
通讯作者地址：[Yan, B]Shandong Univ, Sch Chem & Chem Engn, Jinan 250012, Shandong, Peoples R China.
来源：Journal of the American Chemical Society
摘要：To conquer complex and devastating diseases such as cancer, more coordinated and combined attack strategies are needed. We suggest that these can be beautifully achieved by using nanoconstruct design. We present an example showing that neuroblastoma cells are selectively killed by a nanoconstruct that specifically targets neuroblastoma cells, pushes cells to the vulnerable phase of the cell cycle, and greatly enhances radiation-induced cell death. The success of this multipronged attack approach launched by cell-embedded nanoconstructs demonstrates the power and flexibility of nanotechnology in treating cancer, a difficult task for a small molecule.