标题:Organocatalytic Enantioselective Oxidative C-H Alkenylation and Arylation of N-Carbamoyl Tetrahydropyridines and Tetrahydro-beta-carbolines
作者:Liu, Xigong;Meng, Zhilin;Li, Chengkun;Lou, Hongxiang;Liu, Lei
作者机构:[Liu, X] Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China;[ Meng, Z] 更多
通讯作者:Liu, Lei
通讯作者地址:[Liu, L]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Peoples R China.
来源:Angewandte Chemie
出版年:2015
卷:54
期:20
页码:6012-6015
DOI:10.1002/anie.201500703
关键词:asymmetric organocatalysis;carbamates;C-H functionalization;tetrahydropyridines;tetrahydro-beta-carbolines
摘要:The first organocatalytic enantioselective C-H alkenylation and arylation reactions of N-carbamoyl tetrahydropyridines and tetrahydro-beta-carbolines (THCs) are described. The metal-free processes represent an efficient and straightforward approach to a variety of structurally and electronically diverse a-substituted tetrahydropyridines and THCs in good yields with excellent regio- and enantioselectivities. Preliminary control experiments provide important insights into the reaction mechanism.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:47
Scopus被引频次:45
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928890908&doi=10.1002%2fanie.201500703&partnerID=40&md5=e73876ecacac2d62b4a6c83cd3ec6b59
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