标题:Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation
作者:Ma, Chunhua; Cao, Jiangying; Liang, Xuewu; Huang, Yongxue; Wu, Ping; Li, Yingxia; Xu, Wenfang; Zhang, Yingjie
作者机构:[Ma, Chunhua; Wu, Ping; Li, Yingxia] Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China.; [Ma, Chunhua; Cao, Jiangying; Liang 更多
通讯作者:Zhang, YJ
通讯作者地址:[Zhang, YJ]Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China.
来源:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
出版年:2016
卷:108
页码:21-27
DOI:10.1016/j.ejmech.2015.11.021
关键词:Aminopeptidase N; Inhibitors; Leucine ureido derivatives; Synthesis
摘要:Aminopeptidase N (APN/CD13) over -expressed on tumor cells and tumor microenvironment, plays critical roles in tumor invasion, metastasis and angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 7a had the most potent inhibitory activity against APN with the ICso value of 20 nM, which could be used for further anticancer agent research. (C) 2015 Elsevier Masson SAS. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:6
Scopus被引频次:6
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948657060&doi=10.1016%2fj.ejmech.2015.11.021&partnerID=40&md5=1c9d701beab96835bdfe28af55c30ab2
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